PLASMA INSULIN RESPONSE DURING ORAL GLUCOSE TOLERANCE TESTS IN NEWBORNS OF NORMAL AND GESTATIONAL DIABETIC MOTHERS

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Abstract
The plasma insulin, growth hormone, free fatty acids (FFA), and blood glucose responses to the oral ingestion of glucose were studied in eight infants of gestational diabetic mothers (IGDM) and in 11 normal newborns during the first 24 hours of life. Fasting blood sugars and growth hormone values were similar in the IGDM and the normal. Fasting plasma insulin values were significantly higher (14 ± 2 µU/ml) in the IGDM than those in the normal (7 ± 1 µU/ml), and FFA values were significantly lower (1268 ± 42 µEq/l versus 1627 ± 155 µEq/l). Blood glucose values at each sampling interval after the ingestion of glucose were significantly lower in the IGDM than those in the normal. Plasma insulin responses were prompt in the IGDM and delayed in the normal newborns; corresponding values at 30 minutes were 30 ± 6 µU/ml in the IGDM and 15 ± 3 µU/ml in the normals.

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