MYELOPROLIFERATIVE SYNDROMES - UNIQUE PRESENTATION OF CHRONIC MYELOGENOUS LEUKEMIA (CML) AS A PRIMARY TUMOR OF BONE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 52  (4) , 793-801
Abstract
A 45 yr old female presented with a rapidly enlarging bony tumor that was eventually identified as a Philadelphia chromosome (Ph1)-positive myeloproliferative disorder with extramedullary blastic transformation. This transformation occurred without demonstrable chronic or acute leukemic phase. She had no history of a chronic or prodromal illness in spite of a bone marrow biopsy showing myelofibrosis and liver biopsy documenting extramedullary hematopoiesis. This case represents a unique constellation of features of the myeloproliferative syndrome in which the diagnosis was obscure until special strains of the bony tumor and cytogenetic studies were performed.