Biochemical Modifications of Pulmonary Surfactant after Bromhexine Derivate Injection

1 January 1979

journal article
research article
Published by S. Karger AG in Respiration

Vol. 37 (4) , 215-219
https://doi.org/10.1159/000194030

Abstract

The influence of bromhexine metabolite VIII [NA 872] was studied on phospholipid and fatty acid composition comparative to controls. The s.c. injection of NA 872 in rabbits produces on pulmonary surfactant an increase of 43% of total phospholipids. This change in the distribution of phospholipids was shown by the increase of 53% of phosphatidylcholines. A rise of 61.9-74.4% of palmitic acid appears in the phosphatidylcholines of the pulmonary surfactant. The specific activity of the phosphatidylcholines rose by 31%.

Keywords

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