Effects of Duty-Cycle Distribution on Pulsed Magnetic Field Modulation of Lsa Tumors in Mice

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Abstract
Eight-10 wk old male and female C57NA/Fe mice were each injected with 106 cells of LSA ascites tumor. On day 5, the mice received 5 mg/kg of BCNU [1,3-bis[2-chloroethyl]-1-nitrosourea], were sorted into sexually distinct groups of 4-6 animals, and then placed into an asymmetric 15 Hz pulsed magnetic field for 2 additional days. The fields were turned on for cycles of 1/1, 2/2, 4/4, 6/6, 12/12 and 24/0 h. Apparently, the system can respond selectively to the various 50% duty cycles, it ignores the 100% duty cycle. The responses were uniformly positive for the 12/12 and negative for the 6/6 h, regimes, but were strongly sexually dimorphic for other regimes.