A novel method to prepare monodisperse microparticles
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Journal of Microencapsulation
- Vol. 15 (6) , 715-723
- https://doi.org/10.3109/02652049809008254
Abstract
The membrane emulsification method was adopted to prepare monodisperse albumin microspheres. Uniform-sized emulsion droplets were successfully obtained by passing albumin solution through the membrane into kerosene at appropriate applied pressures. After heating the emulsion, monodisperse albumin microspheres were prepared and the heat-denaturing process itself did not affect their monodispersity once uniform emulsion droplets had been prepared. The shape and size of the albumin microspheres were strongly dependent on the concentration of the albumin solution and the heat denaturing temperature. Lower albumin concentrations produced non-spherical particles and higher denaturing temperatures made the particles smaller. Incorporated riboflavin released quite rapidly from the albumin microspheres, and increases in both albumin concentration and denaturing temperature caused the drug release to be sustained, presumably because a rigid and dense matrix was formed within the albumin microspheres.Keywords
This publication has 6 references indexed in Scilit:
- Preparation of Poly(D,L-lactide) and Copoly(lactide-glycolide) Microspheres of Uniform SizeJournal of Pharmacy and Pharmacology, 1996
- Albumin microspheres as a means of drug delivery to the lung: analysis of the effects of process variables on particle sizes using factorial design methodologyInternational Journal of Pharmaceutics, 1994
- Preparation of polyamide microcapsules having narrow size distributionsJournal of Microencapsulation, 1994
- Effect of particle size on phagocytosis of latex particles by guinea-pig polymorphonuclear leucocytesJournal of Biomaterials Science, Polymer Edition, 1991
- The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to RatsJournal of Pharmacy and Pharmacology, 1989
- A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discsJournal of Controlled Release, 1987