L‐asparaginase effect on antithrombin‐III levels

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Abstract
The effect of L‐asparaginase (L‐asp) therapy on circulating antithrombin‐III (AT‐III) was monitored in three patients with acute lymphoblastic leukemia. Serial determination for AT‐III by both a functional assay and an immunologic assay demonstrated a rapid decrease in serum AT‐III levels, followed by a protracted recovery beyond the period of L‐asp exposure. One of the three patients developed a reversible venous thrombosis of the arm. The mechanism of the L‐asparaginase effect may be related to peripheral degradation of AT‐III or to inhibition of production.