Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus
Open Access
- 1 January 1987
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 15 (17) , 7067-7079
- https://doi.org/10.1093/nar/15.17.7067
Abstract
The nucleotide sequence of the 5′ untranslated region of foot and mouth disease virus (FMDV), serotype A10 has been determined. This completes the first total genomic sequence for any one serotype of FMDV. Analysis of the sequence to the 3' side of the poly (C) tract reveals the presence of a 24 nucleotide repeated motif which has homologies with a sequence located upstream of the transcriptional initiation site from several mammalian fibrinogen genes. The function of this element 1n FMDV is unclear. However, computer analysis of this region predicts the presence of a high degree of secondary and tertiary structure in which these repeats form an important part. The implications of these predictions are discussed.Keywords
This publication has 24 references indexed in Scilit:
- Poliovirus temperature-sensitive mutant containing a single nucleotide deletion in the 5′-noncoding region of the viral RNAVirology, 1986
- Secondary structure of poliovirus RNA: Correlation of computer-predicted with electron microscopically observed structureVirology, 1986
- Two Initiation Sites for Foot-and-Mouth Disease Virus Polyprotein in vivoJournal of General Virology, 1985
- Analysis of the Secondary Structure of the Poly(C) Tract in Foot-and-Mouth Disease Virus RNAsJournal of General Virology, 1985
- Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genomeNature, 1985
- Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiencyCell, 1985
- The sequence of foot-and-mouth disease virus RNA to the 5′ side of the poly(C) tractGene, 1985
- Identification of amino acid and nucleotide sequence of thefoot-and-mouth disease virus RNA polymeraseVirology, 1983
- A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragmentsGene, 1982
- The nucleotide sequence of cDNA coding for the structural proteins of foot-and-mouth disease virusGene, 1982