Stereocontrolled Total Synthesis of Lipoxins B
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (06) , 453-461
- https://doi.org/10.1055/s-1986-31673
Abstract
A stereocontrolled total synthesis of six lipoxin B isomers are described. The flexible and stereoselective strategy involves Sharpless asymmetic epoxidation and pinylborane asymmetic reduction to secure the three hydroxyl-bearing stereocenters and a Wittig-type as well as palladium(0)-copper(I) coupling reactions to construct the carbon skeleton of the target molecules.Keywords
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