Streptozotocin Treatment of a Pancreatic Tumour Producing VIP and Gastrin Associated with Verner‐Morrison Syndrome

Publisher Website
Google Scholar
Abstract
A 57-year-old male patient with metastasizing non-beta islet cell carcinoma of the pancreas is described. Both gastrin and VIP [vasoactive intestinal polypeptide] levels were elevated and the patient suffered from a syndrome of pancreatic cholera and hyperacidity. The tumor contained gastrin and VIP as demonstrated by immunofluorescence. The patient also had a history of familial renal stone formation and parathyroid nodular hyperplasia. Resection of pancreatic tumor in 1973 resulted in 4 years without symptoms. In 1977 definite signs of multiple hepatic metastases appeared. These signs disappeared after streptozotocin given in a dosage of 2 g 3 times at weekly intervals. The patient has remained well for 20 mo. after this treatment. The causative agents for the clinical syndrome in this case are discussed in view of circulating hormone levels.