Increases in Plasma Growth Hormone Concentration and Naso-Anal Length in Rats Following Isolation of the Medial Basal Hypothalamus

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Abstract
The effects of surgical isolation of the medial basal hypothalamus (MBH) on growth were studied in adult female rats. Isolation of MBH caused a gradual increase in naso-anal (N-A) length. N-A length was significantly increased 92 days after surgery and the augmented rate of growth continued until autopsy at 139 days. The increase in N-A length was accompanied by a marked gain in body weight and by conspicuous obesity. Non-stress and stress levels of plasma growth hormone (GH) were determined by radio-immunoassay at 7–11 weeks after surgery. Rats with MBH isolation had circulating non-stress levels of GH that were approximately 6 times higher than those of controls (p

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