Biochemical Changes in Human Cervical Connective Tissue after Local Application of Prostaglandin E2
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 15 (5) , 291-299
- https://doi.org/10.1159/000299423
Abstract
Intracervical application of prostaglandin E2 in the late first trimester induces (1) softening of the cervix tissue; (2) increase in sulfated glycosaminoglycans (18 ± 12%, mean ± SEM): (3) no change in hyaluronic acid and water; (4) decrease in pepsin-extractable collagen, and (5) apparent decrease in collagenase. A high activity of collagenase in combination with a replacement of collagen with sulfated glycosaminoglycans may be of importance for the ripening process.Keywords
This publication has 3 references indexed in Scilit:
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- Stimulatory effect of prostaglandins on the production of hexosamine-containing substance by cultured fibroblasts (3) induction of hyaluronic acid synthetase by prostaglandin F2αProstaglandins, 1977
- Synthetic substrates for vertebrate collagenaseBiochemical Medicine, 1977