Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases
- 1 October 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 175 (2) , 289-293
- https://doi.org/10.1016/0014-5793(84)80753-x
Abstract
Six major basic cytosolic glutathione transferases from rat liver catalyzed the conversion of leukotriene A4 methyl ester to the corresponding leukotriene C4 monomethyl ester. Glutathione transferasc 4‐4, the most active among these enzymes, had a V maxof 615 nmol · min−1 · mg protein−1 at 30°C in the presence of 5 mM glutathione. It was followed in efficiency by transferase 3–4 which had a V max of 160 nmol · min−1 · mg−1 under the same conditions. Transferases 1‐1, 1‐2, 2‐2 and 3‐3 had at least 30 times lower V max values than transferase 4‐4.Keywords
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