ADDITIVE EFFECT OF 5-HYDROXYTRYPTOPHAN AND PARA-CHLOROPHENYLALANINE IN PREVENTING AUDIOGENIC-SEIZURES IN INBRED MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 2  (5-6) , 379-390
Abstract
Convulsive responsiveness of O''Grady mice, inbred for susceptibility to audiogenic seizures, was decreased following treatment with the serotonin [5-hydroxytryptamine (5-HT)] precursor, 5-hydroxytryptophan [5-HTP], or 5-HT depletor, p- chlorophenylalanine [CPA]. Neither agent exerted any antagonistic or synergistic action on the effect of the other. Upon sequential administration, their effects were additive. There was no indication that the increase in brain 5-HT level due to administration of its direct precursor interfered with the protective effect of p-CPA against seizures. Neither was there evidence that p-CPA-induced interruption of biosynthesis which led to severe depletion of brain 5-HT affected the protective action of 5-HTP.

This publication has 0 references indexed in Scilit: