Chlorothiazide Absorption in Humans -Possible Example of Michaelis-Menten Kinetics
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 31 (4) , 181-188
- https://doi.org/10.1159/000138113
Abstract
Chlorothiazide absorption was studied in five healthy adult males at 1,000, 750, 500 and 250-mg dose levels. The 24-hour-absorbed fraction fell from a mean value of 20.15 % of the orally administered dose at the 250-mg level to 8.38% at 1,000 mg. Analysis of data at the four dosage levels for each subject is suggestive of the fact that chlorothiazide absorption is possibly an example of Michealis-Menten kinetics. Possible factors responsible for the saturable absorption are discussed.Keywords
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