INFLUENCE OF GLUCOCORTICOID, ESTROGEN, AND ANDROGEN HORMONES ON TRANSFORMATION OF HUMAN CELLS INVITRO BY FELINE SARCOMA-VIRUS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (6) , 1980-1987
Abstract
Infection of human foreskin cells (D-550) by the Snyder-Theilen strain of feline sarcoma virus produced small but countable foci and demonstrated single-hit dose-response kinetics. Significant quantitative and qualitative enhancement of focus formation was observed when the glucocorticoid hormones, dexamethasone, hydrocortisone, cortisol acetate and prednisolone were added to cell cultures (1.0 .mu.g/ml) 24 h postinfection. Aldosterone, while inducing qualitatively larger foci, did not bring about a quantitative enhancement in total focus number. 17.beta.-Estradiol, progesterone, cortisone acetate, methyltestosterone and estrone elicited little or no effect on focus induction by Snyder-Theilen feline sarcoma virus. Evidence is suggestive of a posttranscriptional effect possibly modulating viral genome expression resulting in an increased efficiency of viral transformation, and an increased proliferation of transformed cells.

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