TOXIC HEPATITIS AND ACUTE YELLOW ATROPHY

27 January 1940

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 114 (4) , 316-318
https://doi.org/10.1001/jama.1940.02810040026007

Abstract

The dangers of cinchophen medication have been repeatedly emphasized by many writers, who have reported large numbers of cases with toxic effects and a high mortality. Bryce¹has collected reports of 190 cases of cinchophen poisoning occurring from 1913 to 1935, 43.6 per cent of the cases being fatal. Snyder and his co-workers²reported 712 deaths from acute yellow atrophy in the hospitals in the state of New York between 1923 and 1933. Evidence presented by Palmer and others³suggests that the use of cinchophen may account for a large percentage of all cases of acute yellow atrophy. Palmer and his co-workers collected reports of 191 cases of liver damage following cinchophen medication with eighty-eight deaths, a mortality of 46.8 per cent. In six of twenty-one fatal cases of acute, subacute or chronic toxic necrosis or cirrhosis there was a history of cinchophen ingestion.³There was

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