EDUCATION OF LYMPHOCYTES INVIVO FOLLOWING A TRANSIENT TAKE OF A MATCHED UNRELATED BONE-MARROW GRAFT IN MAN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (2) , 266-271
Abstract
A patient suffering from aplastic anemia was treated by bone-marrow transplantation from an ABO- and HL-A-identical, MLC[mixed lymphocyte culture]- and CML[cell mediated lympholysis]-negative, unrelated donor. MLC and CML became positive after transplantation indicating that a cellular immune response had developed against lymphocyte determinants not recognized prior to sensitization in vivo. Whether these determinants are governed by genes of the HL-A region is unknown at present.