Bioinformatics Tools for Whole Genomes
- 1 September 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genomics and Human Genetics
- Vol. 1 (1) , 251-279
- https://doi.org/10.1146/annurev.genom.1.1.251
Abstract
The advent of whole-genome data resources—not only sequence but also other genome-scale data collections such as gene expression, protein interaction, and genetic variation—is having two marked, complementary effects on the relatively new discipline of bioinformatics. First, the veritable flood of data is creating a need and demand for new tools for dealing adequately with the deluge, and, second, the unprecedented extent, diversity, and impending completeness of the data sets are creating opportunities for new approaches to discovery based on computational methods.Keywords
This publication has 164 references indexed in Scilit:
- Statistics of local complexity in amino acid sequences and sequence databasesPublished by Elsevier ,2001
- Exploring the new world of the genome with DNA microarraysNature Genetics, 1999
- Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methodsJournal of Molecular Biology, 1998
- Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitationNature Biotechnology, 1998
- Prediction of complete gene structures in human genomic DNAJournal of Molecular Biology, 1997
- Improved Splice Site Detection in GenieJournal of Computational Biology, 1997
- Identification of protein coding regions by database similarity searchNature Genetics, 1993
- Basic Local Alignment Search ToolJournal of Molecular Biology, 1990
- Basic local alignment search toolJournal of Molecular Biology, 1990
- Abraham Wald's Work on Aircraft SurvivabilityJournal of the American Statistical Association, 1984