Estimation of Plasma Fibrinogen, Using Sodium Sulfite Fractionation

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Abstract
A sodium sulfite precipitation procedure is described for the determination of plasma fibrinogen. With 13 percent sodium sulfite solution, fibrinogen may be rapidly salted out of plasma obtained from blood treated with oxalate, citrate, heparin or ethylenediaminetetraacetic (EDTA) acid. The protein concentration is estimated by the biuret reaction. The values compare well with those obtained with a more tedious thrombin precipitation procedure. An ammonium sulfate turbidi-metric method compares unfavorably with both the thrombin precipitation method and the 13 percent sulfite fractionation procedure.