EFFECTS OF SYNTHETIC OESTROGENS AND CARCINOGENS WHEN ADMINISTERED TO RATS BY SUBCUTANEOUS IMPLANTATION OF CRYSTALS OR TABLETS

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Abstract
In a preliminary report [Noble, 1938 a] it was shown that the subcutaneous implantation of crystals of synthetic oestrogenic substances was followed by an inhibition of body-growth for a prolonged period in adult rats, a decreased rate of growth in young animals, and a loss of gonadotrophic hormone from the anterior pituitary gland associated with atrophy of the reproductive organs. These changes could be produced by a substance such as diethylstilboestrol, the molecular structure of which had but little resemblance to the naturally occurring oestrogens. Up to the present time no qualitative differences in the effects of oestrogens on the various parts of the body have been demonstrated. Since a large series of synthetic oestrogenic substances which had been prepared in this laboratory were available for experimental study, it has been possible to compare the effects of representative active substances from different chemical groups with closely related substances of little

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