Chromosome aberration dosimetry using human lymphocytes in simulated partial body irradiation
- 1 May 1973
- journal article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 18 (3) , 421-431
- https://doi.org/10.1088/0031-9155/18/3/007
Abstract
The effect of X-irradiation on the yield of transformed cells in culture has been studied in human peripheral blood lymphocytes. Aberration yields are obtained for mixed cultures prepared from equal numbers of normal and irradiated lymphocytes and from pure cultures of irradiated cells. Comparison of data from these two types of culture show that the observed yield ranges from 90% of the expected at 50 rad to 11% at 700 rad. Poisson analysis demonstrates that for all doses, cells with high levels of chromosome structural damage are not selectively eliminated.Keywords
This publication has 12 references indexed in Scilit:
- Chromosomal damage in human lymphocytes from radio-isotope therapy.Annals of the Rheumatic Diseases, 1973
- Cytogenetic and scanning study of patients receiving intra-articular injections of gold-198 and yttrium-90.Annals of the Rheumatic Diseases, 1973
- Pitfalls in the use of chromosome aberration analysis for bilogical radiation dosimetryThe British Journal of Radiology, 1969
- Factors influencing chromosome aberration yields in the human peripheral leukocyte systemMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1969
- Radiation-induced chromosome damage in human peripheral blood lymphocytes in vitro I. RBE and dose-rate studies with fast neutronsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1969
- The Influence of Temperature at Irradiationin Vitroon the Yield of Chromosomal Aberrations in Peripheral Blood LymphocytesInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1969
- CYTOCIDAL EFFECTS OF RADIATION ON ORGAN CULTURESAnnals of the New York Academy of Sciences, 1961
- X-Ray-Induced Chromosome Aberrations and Reproductive Death in Mammalian CellsThe American Naturalist, 1961