Electron microscopy in the long-term follow-up of Whippleʼs disease, Effect of antibiotics

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Abstract
The EM and light-microscopic findings on jejunal biopsies from a case (human) of Whipple''s disease are described. Seven biopsies were obtained over a 3 yr period. Rapid clinical recovery was accompanied by the disappearance of interstitial and intracellular bacteria from the lamina propria. The pathognomonic PAS[periodic acid-Schiff]-positive material on light microscopy corresponding to the phagocytic vacuoles in the macrophages of the lamina propria decreased markedly in amount but persisted throughout the 3 yr period. The sequential changes in the jejunal mucosa and in particular those occurring in macrophages are described and their relation to pathogenesis discussed.

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