The design, synthesis and biological evaluation of stable ozonides with antimalarial activity
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 1101-1105
- https://doi.org/10.1039/p19960001101
Abstract
The synthesis of variously substituted 8,9,10,11-tetraoxatricyclo[5.2.1.12.6]undecan-4-ones by ozonolysis of various 8-oxabicyclo[3.2.1]oct-6-en-3-ones is described. Several of these stable ozonides exhibited activity (IC50s of 2–20 microgram cm–3) against a chloroquine-resistant strain of the malaria parasite Plasmodium falciparum.Keywords
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