EFFECT OF SURGICAL SYMPATHECTOMY ON THE SENSITIVITY TO EPINEPHRINE OF THE BLOOD VESSELS OF MUSCULAR SEGMENTS OF THE LIMBS 12

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Abstract
Blood flow responses to intraven. and intraarterial epinephrine in the forearm and calf of normal and sympathectomized subjects were measured plethysmographically. Initial vasodilita-tion during intraven. infusions of 10 [mu]g. epinephrine/min. was shown to be greater in sympathectomized than in normally innervated limbs. This increase was attributed to hyper-sensitivity of the vessels in muscular segments of the sympathectomized limbs. Reduction or reversal of the normal 2d phase of vasodilitation in sympathectomized forearms and calves during intraven. epinephrine infusions was interpreted as further evidence of vascular hypersensitivity in sympathectomized muscles. These phenomena occurred in limbs sympathectomized either by preganglionic section or by ganglionectomy.