INTERACTION BETWEEN THEOPHYLLINE AND OESTROGEN IN THE RAT UTERUS
- 1 December 1979
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 83 (3) , 277-284
- https://doi.org/10.1677/joe.0.0830277
Abstract
Theophylline alone or in the presence of 0·001, 0·01, 0·1 or 1 μg oestradiol-17β/100 g body wt increased uterine RNA and protein content 6 h after administration. Uterine oedema induced by physiological doses of oestradiol-17β was increased further in the presence of theophylline. Theophylline decreased the number of eosinophils in the blood and concurrently decreased oestrogen-induced uterine eosinophilia at doses of 0·01,0·1, 1,10 or 30 μg oestradiol-17β/100 g body wt. Oestrogen binding by uterine eosinophils in vitro increased in the presence of theophylline. This effect of theophylline could explain the increase of oestrogen-induced uterine oedema in vivo.This publication has 3 references indexed in Scilit:
- Autoradiogsaphic study of (6.7-3H)oestradiol-17β incorporation into rat uterusSteroids, 1967
- FORMATION OF A CYCLIC ADENINE RIBONUCLEOTIDE BY TISSUE PARTICLESJournal of Biological Chemistry, 1958
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951