Synthesis of Substituted γ-Butyrolactones: β-Hydroxymethyl-, β-Methylene and Cyclopropane Derivatives
- 1 September 1999
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 29 (17) , 2923-2936
- https://doi.org/10.1080/00397919908086464
Abstract
A β-hydroxymethyl-γ-butyrolactone, which is a useful intermediate for the synthesis of several natural products with biological activity, was synthesized with good yield and a reduced number of steps from simple commercially available starting materials. Model compounds of natural products containing the unsaturated γ-butyrolactone unit, such as butenolides and β-methylene-γ-butyrolactones, were also conveniently synthesized from this hydroxymethyl-lactone.Keywords
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