On The Significance of Pulmonary Mean Capillary Co Back Pressure Corrections for Repeated Measurements of DLCODuring Exercise in Man

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Abstract
Steady state pulmonary diffusing capacity for CO (DLCO) during exercise was determined using 0.05% CO in air mixture with and without correction for back pressure of CO in pulmonary capillary blood. Four determinations were performed in each of 38 normal subjects. The results illustrate the quantitative effect of correcting for CO back pressure, which becomes of increasing importance when repeated measurements are performed. In routine determination of DLCO during moderate exercise the corrected DLCO can be predicted as [uncorrected DLCO] x 0.97 + 4.6, without actual determination of CO saturation of blood (SBCO), and the error of the estimate then amounts to 3.7%.