Enterotoxigenic Escherichia coli and Diarrheal Disease in Mexican Children

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Abstract
Enterotoxigenic strains of E. coli were isolated from 8 (16%) of 50 Mexican children admitted to the hospital with diarrhea and from 1 of 50 children hospitalized for nonenteric disorders. All of the toxigenic strains tested elaborated a heat-labile enterotoxin, and in 7 of 9 patients no E. coli capable of concomitant production of heat-stable enterotoxin were found. None of the strains of E. coli with classical enteropathogenic serotypes isolated from 9 patients with diarrhea produced heat-labile or heat-stable enterotoxin. Although the results of this study strongly suggest that enterotoxigenic strains of E. coli are probably responsible for a significant number of cases of diarrhea in an indigenous Mexican pediatric population, further proof requires demonstration of in vivo production of enterotoxin and/or antitoxin.

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