Effect of High Carbon Dioxide and of Low Oxygen Concentration on Fusion Frequency of Flicker

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Abstract
Mixtures of 5% CO2 and 95% O2, and of 14% O2 and 86% N2, produced a significant drop of the fusion frequency of flicker (FFF) within 12 min. in 13 subjects. The drop was faster and greater with the 5% CO2 mixture. There was no correlation between the decrease of the arterial O2 saturation and the decrease of the FFF when breathing the 14% O2 mixture, or between pulmonary hyperventilation and the fall of the FFF when breathing the 5% CO2 mixture. There was a high correlation between the initial value of the FFF and its drop with the 5% CO2 mixture, Some applications of the results to clinical and stress physiology are discussed.