Tau Function and Dysfunction in Neurons
- 1 January 2002
- journal article
- review article
- Published by Springer Nature in Molecular Neurobiology
- Vol. 25 (3) , 213-232
- https://doi.org/10.1385/mn:25:3:213
Abstract
Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.Keywords
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