Prenatal diagnosis of a dup(3p) with holoprosencephaly

Abstract
The prenatal diagnosis of dup(3p) was made in a female conceptus, the father being a known carrier of a balanced translocation t(3;10)(p21;q26). Interruption of pregnancy at 19 weeks showed a fetus with a holoprosencephaly field defect. Two other cases of dup(3p) have been observed in the same family. The malfor‐mations were different in each of the 3 patients, suggesting a considerable degree of variability of dup(3p).

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