Early hypophysial developmental in the chick embryo

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Abstract
The purpose of this study was to determine the developmental interrelationships existing between the lobes of the hypophysis and the prechordal mesoderm in the chick embryo.Using glass needles, operations were performed in ovo on embryos of three to 13 somites. The operative series involved extirpations of the prospective area or precursors of: (1) anterior lobe alone; (2) posterior lobe alone; (3) posterior lobe and the prechordal mesoderm together; and (4) anterior and posterior lobe precursors and the intervening mesoderm.The results of these experiments indicate that there is a mesodermal‐neural sequence in the inductive process which leads to the development of the anterior lobe. Prechordal mesoderm induces the formation of Rathke's pouch. The latter is then influenced to differentiate through a vascular supply arising from the pial plexus of the infundibular region. Contact of the epithelial and neural rudiments of the hypophysis is not necessary.