FETAL LIVER-CELLS PRODUCE BOTH FETAL AND ADULT ERYTHROCYTES IN SEMIALLOGENEIC RADIATION CHIMERAS - POSSIBLE INFLUENCE OF ADULT ENVIRONMENT

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (3) , 586-591
Abstract
Two kinds of erythrocytes are released in the blood of irradiated adult hybrid mice grafted with parental fetal liver cells: fetal antigen-bearing erythrocytes (Ft+ cells) and adult-type Ft- erythrocytes. Both are of parental origin, as determined by immune lysis using histocompatibility alloantigens. The latter cells make up all the recipient''s red blood cells 2 mo. after receipt of the graft, Ft+ cells then being no longer detected. The transient dose of erythropoiesis in irradiated adults grafted with fetal liver cells was confirmed by studying the kinetics of CFU-E [erythropoietic stem cells] populations, as characterized by their ability to give rise to Ft+ or Ft- erythrocytes. The results are discussed in terms of environmental factors that influence erythroid differentiation.