ANTITHROMBOTIC EFFECT OF A MONOCLONAL-ANTIBODY TO THE PLATELET GLYCOPROTEIN IIB/IIIA RECEPTOR IN AN EXPERIMENTAL ANIMAL-MODEL
- 1 September 1986
- journal article
- research article
- Vol. 68 (3) , 783-786
Abstract
A murine monoclonal antibody directed at the platelet glycoprotein IIb/IIIa complex, which blocks platelet aggregation ex vivo, was tested for its antithrombotic effects in an established animal model of acute platelet thrombus formation in partially stenosed arteries. Infusion of 0.7 to 0.8 mg/kg of the F(ab'')2 fragment of the antibody completely blocked new thrombus formation despite multiple provocations, making it the most potent antithrombotic agent tested in this model.This publication has 14 references indexed in Scilit:
- Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries.Circulation, 1984
- Platelet-mediated thrombosis in stenosed canine coronary arteries: Inhibition by nicergoline, a platelet-active alpha-adrenergic antagonistJournal of the American College of Cardiology, 1984
- INHIBITION OF EPINEPHRINE-EXACERBATED CORONARY THROMBUS FORMATION BY PROSTACYCLIN IN THE DOG1984
- A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins IIb and/or IIIa.Journal of Clinical Investigation, 1983
- Influence of the autonomic nervous system on coronary blood flow during partial stenosisAmerican Heart Journal, 1982
- The effects of cigarette smoke and nicotine on platelet thrombus formation in stenosed dog coronary arteries: inhibition with phentolamine.Circulation, 1982
- Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation?Circulation, 1982
- Comparison in anesthetized dogs of the anti-aggregatory and hemodynamic effects of prostacyclin and a chemically stable prostacyclin analog, 6a-carba-PGI2 (carbacyclin)Prostaglandins, 1980
- Norepinephrine and Epinephrine Release and Adrenergic Mediation of Smoking-Associated Hemodynamic and Metabolic EventsNew England Journal of Medicine, 1976
- Platelet aggregation in partially obstructed vessels and its elimination with aspirin.Circulation, 1976