FORMALDEHYDE TOXICITY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 103  (7) , 321-324
Abstract
The presence of formaldehyde in biologically active concentrations in several occupational and environmental atmospheres created concern about the hazards of exposure to these contaminated atmospheres. A review of the clinical and animal toxicologic data demonstrated primary irritant and sensitizing actions of the compound. The minimal concentration of formaldehyde that can be detected by odor is similar to the level that produces minimal irritant effects on the eyes and in the pulmonary airway, thereby serving as a warning of exposure to the compound. The irritant effects are reversible when exposure is discontinued. Some persons show allergic type responses to concentrations of the compound that are well below the odor threshold. The very limited amount of toxicologic data concerned with effects from prolonged and chronic exposures suggest that the compound does not produce specific delayed types of toxicity. The factors that influence establishment of safe conditions or levels of exposure to formaldehyde are discussed.

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