Reduced Hypoxic Pulmonary Vascular Remodeling by Nitric Oxide From the Endothelium
- 1 February 2001
- journal article
- other
- Published by Wolters Kluwer Health in Hypertension
- Vol. 37 (2) , 322-327
- https://doi.org/10.1161/01.hyp.37.2.322
Abstract
We examined whether overproduction of endogenous nitric oxide (NO) can prevent hypoxia-induced pulmonary hypertension and vascular remodeling by using endothelial NO-overexpressing (eNOS-Tg) mice. ...Keywords
This publication has 19 references indexed in Scilit:
- The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxiaJournal of Clinical Investigation, 1999
- l-Arginine Reduces Right Heart Hypertrophy in Hypoxia-Induced Pulmonary HypertensionBiochemical and Biophysical Research Communications, 1999
- Hypotension and reduced nitric oxide-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase.Journal of Clinical Investigation, 1998
- Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMPPublished by Elsevier ,1998
- Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.Journal of Clinical Investigation, 1998
- CELLULAR AND MOLECULAR MECHANISMS OF PULMONARY VASCULAR REMODELINGAnnual Review of Physiology, 1997
- Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF.The Journal of cell biology, 1993
- Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.Journal of Clinical Investigation, 1993
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.Journal of Clinical Investigation, 1989
- The Effect of Chronic Hypoxia on Pulmonary Arteries in Young RatsExperimental Lung Research, 1980