Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p
- 1 September 1994
- journal article
- case report
- Published by Oxford University Press (OUP) in Human Molecular Genetics
- Vol. 3 (9) , 1569-1573
- https://doi.org/10.1093/hmg/3.9.1569
Abstract
Autosomal dominant familial spastic paraplegia (ADFSP) is a genetically heterogeneous neurodegenerative disorder characterized by a spasticity of the lower limbs. A locus causing AD-FSP (FSP1) has been previously mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21 – p24 In five of seven French families and one large Dutch pedigree. The analysis of recombination events and multipoint linkage place FSP2 within a 4 cM interval flanked by loci D2S400 and D2S367.Keywords
This publication has 0 references indexed in Scilit: