Chromosome breaking activity of human feces and its enhancement by transition metals
- 15 September 1979
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 24 (3) , 284-287
- https://doi.org/10.1002/ijc.2910240303
Abstract
Chloroform‐methanol extracts from human fecal samples were found to contain compounds which induce chromosome aberrations in Chinese hamster ovary cells. The induction of chromosome aberrations is stimulated by Cu2+ or Mn2+ and inhibited by Fe2+ or Fe3+. Addition of catalase to the fecal extract or the mixture of fecal extract and Mn2+ reduced the frequency of chromosome aberrations. These properties are indicative of hydroxyradical producing agents.Keywords
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