The Effect of Single Massive Doses of Roentgen Radiation Upon the Liver

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Abstract
Normal adult New Zealand white stock rabbits received local X-irradiation over the liver section of the body with doses ranging from 300 to 100,000 r/air (90 kV). It was measured that 30% of this radiation was absorbed in the skin and that about 38% of the skin dose was delivered to the center of the liver. Histological study revealed edema, hyperemia and leukocytic infiltration, most marked in the central part of the lobule and polymorphonuclear leukocytic infiltration in the portal areas. The smaller doses produced only slight swelling of the liver cells, while the highest doses resulted in severe necrosis. Repair processes were noticed to occur rapidly, the extent of repair showing definite correlation to the radiation dose used.