Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice
- 1 March 1999
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 43 (3) , 697-698
- https://doi.org/10.1128/aac.43.3.697
Abstract
To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1β, indicating that FOF alters inflammatory cytokine production after LPS stimulation.Keywords
This publication has 14 references indexed in Scilit:
- PARADOXICAL SYNERGISTIC EFFECTS OF TUMOUR NECROSIS FACTOR AND INTERLEUKIN 1 IN MURINE GUT-DERIVED SEPSIS WITH PSEUDOMONAS AERUGINOSACytokine, 1999
- Efficacies of alkaline protease, elastase and exotoxin A toxoid vaccines against gut-derived Pseudomonas aeruginosa sepsis in miceJournal of Medical Microbiology, 1998
- ADVERSE EFFECTS OF TUMOUR NECROSIS FACTOR IN CYCLOPHOSPHAMIDE-TREATED MICE SUBJECTED TO GUT-DERIVEDPSEUDOMONAS AERUGINOSASEPSISCytokine, 1997
- Recent Progress in the Identification of Pathogenic Factors of Pseudomonas aeruginosaJournal of Infection and Chemotherapy, 1996
- Mortality rates amongst mice with endogenous septicaemia caused by Pseudomonas aeruginosa isolates from various clinical sourcesJournal of Medical Microbiology, 1993
- Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1.The Journal of Immunology, 1988
- Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemiaNature, 1987
- Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of EndotoxinScience, 1985