Further Studies on the in Vitro Replication of Lactic Dehydrogenase Virus in Peritoneal Macrophage Cultures

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Abstract
Lactic dehydrogenase virus has been cultivated in adult mouse peritoneal macrophage cultures for at least 21 days. The supernatant titer was higher than the cell titer at all times after infection up to 24 hours, indicating rapid release of virus from the host cell. When tissue culture cells were infected with a high multiplicity, virus replication occurred within 3 hours, and the maximum titer was reached within 15 hours, indicating a short growth cycle. Serial passage experiments were performed in three different strains of macrophage cultures. There was no apparent difference in the ability of these three strains of macrophages to support virus replication.

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