Effects of Corticosterone and Microgravity on Inflammatory Cell Production of Superoxide
- 1 July 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Leukocyte Biology
- Vol. 50 (1) , 69-76
- https://doi.org/10.1002/jlb.50.1.69
Abstract
In this investigation we studied the effects of corticosterone and microgravity on Propionibacterium acnes-induced inflammatory cells ability to produce superoxide (O2 -). We found in vitro and in vivo exposure of murine peritoneal inflammatory cells to corticosterone did not inhibit the O2 - response. We also found that in microgravity P. acnes-induced inflammatory cells were capable of producing four times as much O2 - as at 1g. Therefore, neither corticosterone nor microgravity experienced during parabolic flight prevents an O2 - response by inflammatory cells.Keywords
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