Formation of a Lactam Derivative on Direct Benzylation ofN-Acetylneuraminic Acid α-Methyl Ketoside1
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (07) , 561-562
- https://doi.org/10.1055/s-1992-21414
Abstract
A novel route for efficient hydroxy protection of N-acetylneuraminic acid (Neu5Ac) is reported. Starting from various Neu5Ac derivatives 1a-1d, the corresponding perbenzylated lactam derivatives 2a-2d were obtained. Further investigations on these lactam derivatives demonstrate their broad applicability in synthesis of sialic acid analogues.Keywords
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