Cell lines with spontaneous secretion of pregnancy-associated α2-globulin

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Abstract
Pregnancy-associated α2-globulin (PA α2G) was quantitated by radioimmunoassay in culture media from 34 exponentially growing human cell lines. Only 8/34 cell lines produced PA α2G. The highest secretion was found in cell lines of histiocytic lymphoma origin while it was low in some carcinoma-derived lines. The results may support an assumption that PAα2G is a normal cell product of B-lymphoid, monocytic and epithelial cells but may also simply indicate that ectopic PAα2G production is especially common in tumors derived from such cells. The availability of PAα2G-producing cell lines should facilitate studies of the immunoregulatory role of this protein.
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