THE CAUSE OF THE DELAYED CLOTTING OF HEMOPHILIC BLOOD

Publisher Website
Google Scholar
Abstract
The results of an extensive study made upon 3 cases of hemophilia are reported. The prothrombin was isolated by 3 different methods. The results of many experiments showed that the prothrombin in hemophilic blood does not differ either in quantity or quality from that occurring in normal blood, but the platelets possess unusual stability. In blood smears the latter were found, single or in groups, 1-2 hrs. after the blood was shed. Platelet counts made upon shed hemophilic blood showed a nearly normal number up to an hour, with a sudden diminution just preceding clotting (2 hrs.). This stability of the platelets possibly accounts for the delay in clotting of the hemophilic blood and constitutes the characteristic defect in hemophilia.

This publication has 0 references indexed in Scilit: