Biologically active conformations of thymopentin Studies with conformationally restricted analogs
- 1 March 1991
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 37 (3) , 198-209
- https://doi.org/10.1111/j.1399-3011.1991.tb00271.x
Abstract
Four cyclic analogs of thymopentin were synthesized and evaluated for biological activity on the human T cell line CEM. Three of these conformationally restricted analogs were biologically active. The one analog which most closely mimicked the conformation predicted from NMR and theoretical energy minimization calculations proved to be inactive. These studies establish that the biologically active conformations of thymopentin differ from the most probable conformation predicted from solution NMR and theoretical energy minimization studies.Keywords
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