Stimulation of Cyclic AMP and Progesterone Synthesis by LH, PGE2 and Isoproterenol in the Bovine CL in vitro
- 1 November 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 17 (4) , 514-518
- https://doi.org/10.1095/biolreprod17.4.514
Abstract
Isoproterenol, a .beta. adrenergic agonist, stimulates the adenyl cyclase-cyclic[c]AMP system in bovine CL [corpus luteum] slices and increases progesterone production. Propranol, a .beta. adrenergic blocker, inhibited stimulation of cAMP and progesterone synthesis by isoproterenol, suggesting that the bovine luteal cell membrane possesses steroidogenically functional .beta. adrenergic receptors. Since propranolol inhibited LH [luteinizing hormone] and PGE2 [prostaglandin] stimulation of progesterone synthesis, had no effect on cAMP accumulation, then propranolol inhibition of progesterone synthesis by LH and PGE2 probably is not related to .beta. blockade.This publication has 11 references indexed in Scilit:
- Exogenous Hormones and Luteal Function in Hysterectomized and Intact HeifersJournal of Dairy Science, 1969
- Histochemical and Chemical Studies of the Autonomic Innervation of the OvaryEndocrinology, 1967
- The adrenergic nerve supply to the female reproductive tract of the catJournal of Anatomy, 1967
- The stimulation of progesterone synthesis in bovine corpora lutea by adenosine 3', 5'-monophosphate (1)Steroids, 1966
- Optical Isomers of PropranololNature, 1966
- Influence of Luteinizing Hormone on Corpus Luteum Metabolism and Progesterone Biosynthesis Throughout the Bovine Estrous Cycle11Endocrinology, 1966
- Luteotropic Properties of Luteinizing Hormone and Nature of Oxytocin Induced Luteal Inhibition in CattleJournal of Dairy Science, 1965
- Effects of Luteinizing Hormone on Progestin Biosynthesis in the Luteinized Rat OvaryEndocrinology, 1964
- Specificity of Gonadotropin Stimulation of Progesterone Synthesis in Bovine Corpus Luteumin VitroEndocrinology, 1964
- An Action of Gonadotropin in VitroJournal of Biological Chemistry, 1962