Defective Leptin/Leptin Receptor Signaling Improves Regulatory T Cell Immune Response and Protects Mice From Atherosclerosis

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Abstract
Objective— Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality. However, the precise molecular pathways responsible for this c... Leptin, a hormone that increases with obesity, was suggested to either accelerate or protect from atherosclerosis. Here, we identify a critical role for leptin/leptin receptor pathway in the modula...