Amphotropic host range of naturally occuring wild mouse leukemia viruses

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Abstract
Seven murine leukemia virus field isolates (uncloned) from wild mice (Mus musculus) of 4 widely separated areas in southern California [USA] show an unusually wide in vitro host range. They replicate well in human, feline, canine, guinea pig, rabbit, rat and mouse cells, whereas bovine, hamster and avian cells are resistant. Since this host range includes that of both mouse tropic (ecotropic) and xenotropic murine leukemia viruses, they are designated as amphotropic. No purely xenotropic virus component is detectable in these field isolates. They may represent the wild or ancestral viruses from which the ecotropic and xenotropic murine leukemia virus strains of laboratory mice were derived.