Programmed feeding as a model of chronic alcoholism in the rat
- 7 October 1977
- journal article
- Published by Wiley in Annals of Neurology
- Vol. 2 (4) , 311-314
- https://doi.org/10.1002/ana.410020409
Abstract
Programmed‐feeding polydipsia results in a reliable model of chronic alcoholism in the rat. High oral ethanol consumption and a predictable withdrawal reaction associated with audiogenic seizures are produced. The maintenance of high blood ethanol levels for three weeks in 18 male Charles River rats was associated with audiogenic seizures after 6 to 8 hours of withdrawal. These chronic alcoholic rats had enhanced blood clearance of ethanol. The cerebral cortical crude mitochondrial function showed a decrease in total and magnesium‐dependent adenosine triphosphatase activity in alcoholic and control (water‐fed) rats compared with normal rats.Keywords
This publication has 10 references indexed in Scilit:
- Polydipsia-Induced Alcohol Dependency in Rats: A ReexaminationScience, 1976
- Maximization of Ethanol Intake in the RatPublished by Springer Nature ,1975
- Chronic Ingestion Techniques for the Production of Physical Dependence on EthanolPublished by Springer Nature ,1973
- Evaluation of a Polydipsia Technique to Induce Alcohol Consumption in MonkeysPublished by Springer Nature ,1973
- Behavioral Maintenance of High Concentrations of Blood Ethanol and Physical Dependence in the RatScience, 1972
- Factors that modify the metabolism of ethanol in rat liver and adaptive changes produced by its chronic administrationBiochemical Journal, 1970
- Schedule-induced consumption of ethanol: Calories or chemotherapy?Physiology & Behavior, 1970
- Ethanol consumption under conditions of psychogenic polydipsiaPhysiology & Behavior, 1968
- Inhibition of brain microsomal adenosine triphosphatases by general depressantsArchives of Biochemistry and Biophysics, 1967
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951